da Silva Souza, LorenaLorenada Silva SouzaBonnail, EstefaniaEstefaniaBonnailAlves Maranho, LucianeLucianeAlves MaranhoHermes Pusceddu, FabioFabioHermes PuscedduCortez, Fernando SanziFernando SanziCortezCesar, AugustoAugustoCesarRibeiro, Daniel ArakiDaniel ArakiRibeiroRiba, InmaculadaInmaculadaRibade Souza Abessa, Denis M.Denis M.de Souza AbessaDelValls, AngelAngelDelVallsSeabra Pereira, Camilo DiasCamilo DiasSeabra Pereira2025-12-302025-12-3020211879-3363https://hdl.handle.net/20.500.12740/23884The increasing CO2-concentrations in the atmosphere promote ocean acidification. Seawater chemistry changes interact with contaminants, such as illicit drugs in the coastal zones. This work evaluates impacts of pH decrease and crack-cocaine exposure on the commercial mussel Perna perna through biomarker responses (lysosomal membrane stability, lipid peroxidation, and DNA strand breaks). The organisms were exposed to different crack-cocaine concentrations (0.5, 5.0, and 50 mu g L-1) combined with different pH values (8.3, 8.0, 7.5, 7.0, 6.5, and 6.0) for 96 h. Crack-cocaine in the different acidification scenarios triggered cyto-genotoxicity, which affected the overall health of mussels exposed to cocaine environmentally relevant concentration. This study produced the first data on biomarker responses associated with CO2-induced acidification and illicit drugs (crack-cocaine) in marine organisms.Acceso AbiertoCrack cocaineOcean acidificationMarine musselCO2 enrichmentBiomarkershttp://dx.doi.org/10.1016/j.marpolbul.2021.112735