Ramirez-Guerrero G.Muller-Ortiz H.Jara-Vilugron F.Pedreros-Rosales C.Gonzalez-Burboa A.Silva J.P.Torres-Cifuentes V.Villagran-Cortes F.Aldo Vera Calzaretta2025-03-142025-03-142022https://hdl.handle.net/20.500.12740/17243Background: Therapeutic Plasma Exchange (TPE) is a procedure in which plasma and harmful macromolecules are separated from the rest of the blood components by centrifugation or filtration through membranes and are replaced with solutions with albumin and/or plasma. Aim: To communicate our experience using TPE by filtration. Material and Methods: Review of records of 655 TPE sessions performed in 102 patients aged 50 ± 18 years (64% women). The requirement of renal replacement therapy (RRT) and seven days and one year mortality were recorded. Results: Forty five percent of patients had hypertension or diabetes. The main indications for TPE were pulmonary-renal syndrome (PRS) (62%) and antibody mediated graft rejection (29%), followed by neurological diseases (36%). Fifteen percent of patients required RRT for one year. Mortality at seven days and one year was 20 and 30%, respectively. Out of the total of deaths associated with kidney diseases, 88% corresponded to PRS and ANCA vasculitis. The main complications were thrombocytopenia in 41%, hypocalcemia in 18%, and hypotension in 16%. Conclusions: In our experience, TPE by filtration is a safe technique, with mild and preventable complications. Despite this, the reported mortality is high, which reflects the severity of the diseases that motivated the indication for TPE. © 2022 Sociedad Medica de Santiago. All rights reserved.PDFAutoimmune DiseasesBlood Component RemovalPlasma ExchangeVasculitisArtículohttp://dx.doi.org/10.4067/S0034-98872022000200147