Baroreflex and chemoreflex interaction in high-altitude exposure: possible role on exercise performance

Pablo Alvarez-AraosSergio JiménezCamila Salazar-ArdilesCristian Núñez-EspinosaValeria PaezMaria Rodriguez-FernandezAntoine RaberinGregoire P. MilletRodrigo IturriagaDavid C. AndradeJIMENEZ TORRES SERGIO RODRIGO2025-05-232025-05-232024Front. Physiol. 15:1422927. https://doi.org/10.3389/fphys.2024.1422927https://hdl.handle.net/20.500.12740/22475This review explores the interaction between the baroreflex and chemoreflex in the context of high-altitude (HA) exposure, highlighting how these mechanisms influence cardiorespiratory regulation and exercise capacity. Evidence shows that hypoxia potentiates the chemoreflex and suppresses the baroreflex, leading to reduced parasympathetic activity and impaired performance. The review proposes that the chemoreflex-baroreflex interaction could modulate vagal control, affecting physiological adaptation during HA exposure. Future research is needed to clarify the mechanisms underlying this interaction and its potential modulation.application/pdfchemoreflexbaroreflexhypoxiaaltitude physiologyvagal toneexercise adaptationBaroreflex and chemoreflex interaction in high-altitude exposure: possible role on exercise performanceother10.3389/fphys.2024.1422927