Background: The Chilean population has experienced increased longevity in recent decades, leading to an increased incidence of and mortality from neurodegenerative diseases such as Parkinson's disease (PD). PD is a chronic degenerative condition that affects the central nervous system. The main objective of this research is to evaluate the effect of 12-week programs of tonic, isometric, and isometric/vibratory muscular strength training while controlling the manipulation of the intensity variable on motor and non-motor symptomatology in PD patients. The secondary objective is to assess the levels of muscular strength in PD patients and their relationship with motor and non-motor symptomatology. Methods: A parallel-group, randomized trial will randomly assign (n = 34) people of both sexes with Parkinson's disease between stages I-III Hoehn and Yahr (H&Y), aged between 50 and 70 years to one of the experimental groups, in which they will undergo a total of 24 strength training sessions during 12 weeks. During the intervention period, the participants will be advised not to undertake additional exercise programs, to avoid substances that may disrupt metabolism and circadian cycles, and to maintain their medication regimen. The primary or motor evaluation of rest tremor will be performed with an accelerometer (Actigraphy), balance with the Mini-BESTest balance test, gait speed with the Ten Meters Walk Test, and non-motor symptomatology through anxiety, depression (MDS-UPDRS), and quality of life (PDQ-39) questionnaires. The Secondary evaluation of muscle strength will be performed with a functional electromechanical dynamometer. Discussion: Established as a hypothesis is that manipulating intensity variables in 12-week tonic, isometric, and isometric/vibratory muscle strength training programs has an effect on motor and non-motor symptomatology in people with Parkinson's disease. The research will establish the extent to which controlled muscular strength training has an effect on relevant factors related to motor and non-motor symptomatology. C1 [Andrades-Ramirez, Oscar] Univ Amer, Fac Salud & Ciencias Sociales, Inst Deporte, Ciencias Act Fis, Concepcion 4030000, Chile. [Ulloa-Diaz, David] Univ Catolica Santisima Concepcion, Dept Sports Sci & Phys Conditioning, Fac Educ, Concepcion 4030000, Chile. [Guede-Rojas, Francisco] Univ Andres Bello, Exercise & Rehabil Sci Inst, Fac Rehabil Sci, Sch Phys Therapy, Santiago 7591538, Chile. [Araya-Sierralta, Sergio] Univ Atacama, Fac Human & Educ, Copiapo 1531772, Chile. [Munoz-Bustos, Gustavo] Univ Santo Tomas, Escuela Nutr & Dietet, Fac Salud, Iquique 1100000, Chile. [Arroyo-Jofre, Patricio] Univ San Sebastian, Fac Educ, Santiago 8420524, Chile. [Chirosa-Rios, Luis-Javier] Univ Granada, Fac Sport Sci, Dept Phys Educ & Sport, Granada 18011, Spain. C3 Universidad de Las Americas - Chile; Universidad Catolica de la Santisima Concepcion; Universidad Andres Bello; Universidad de Atacama; Universidad Santo Tomas; Universidad San Sebastian; University of Granada