Objective: to compare the relationships between emotional symptomatology and perceived social support according to gender identity and sexual orientation in LGBTQ+ university students. Methods: 322 Chilean LGBTQ+ college students answered an online survey based on sociodemographic information and validated instruments. Analysis of variance and linear regressions were made. Results: Transgender people have more emotional symptoms and stress and less perceived social support from family than the rest of LGBTQ+ students. Depression and anxiety are negatively associated with perceived social support from friends and family. Conclusions: Perceived social support decreases emotional symptomatology even when controlling for current stress in LGBTQ+ students. © 2021 Taylor & Francis Group, LLC.