Abstract Mapping the local and distant Universe is key to our understanding of it. For decades, the Sloan Digital Sky Survey (SDSS) has made a concerted effort to map millions of celestial objects to constrain the physical processes that govern our Universe. The most recent and fifth generation of SDSS (SDSS-V) is organized into three scientific “mappers”: the Milky Way Mapper, which aims to chart the various components of the Milky Way and constrain its formation and assembly; the Black Hole Mapper, which focuses on understanding supermassive black holes in distant galaxies across the Universe; and the Local Volume Mapper, which uses integral field spectroscopy to map the ionized interstellar medium in the Local Group. This paper describes the scope and content for the nineteenth data release (DR19) of SDSS, which is the most substantial to date in SDSS-V. DR19 is the first to contain data from all three mappers. Additionally, we also describe nine value-added catalogs that enhance the science that can be conducted with the SDSS-V data. Finally, we discuss how to access SDSS DR19 and provide illustrative examples and tutorials.