The aim of this article is to analyze, from a comparative perspective, personal preventive measures and their regulation in the context of corruption associated with transnational organized crime. To achieve this, two closely related factors will be addressed: on the one hand, the political-criminal projection of these precautionary measures in the crime of corruption associated with transnational organized crime and, on the other hand, how and in what way different countries regulate their concurrence and application in this type of crime. In this way, together with a critical assessment of their assumptions and criteria of correctness, it will be concluded that only through the establishment of a comprehensive criminal policy based on uniform, ductile and flexible premises, it will be possible to guarantee that these precautionary measures are implemented in a balanced manner, thus allowing to harmonize their effectiveness with the guarantees that their concrete application entails. © 2025 Elsevier B.V., All rights reserved.